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Testosterone and DHEA: The Source of Healthy Male Sexual Function

Testosterone is a powerful male sex hormone. Produced in the testes, testosterone promotes the fundamental components of healthy sexual function, including gonadal development, sex drive, ejaculation, penis sensitivity, and erectile function.

Research shows a particularly strong relationship between sexual interest and testosterone levels as men reach middle and advanced age. As we age, the testes begin to produce less and less testosterone. By the age of 60, our testosterone levels may only be half their youthful peaks. This drop in hormone levels is believed to precede both a drop in sexual interest and erection frequency.

If you have low testosterone, you may feel a lack of sexual interest combined with overall fatigue. You may also experience reduced muscle mass, weight gain, irritability and depression. Other health conditions commonly associated with sexual dysfunction in men, such as diabetes, poor cardiovascular health, and thyroid imbalances, can be strongly influenced — and some believe even partly triggered — by chronic testosterone deficiencies.

Testosterone therapy is among the most widely used treatments for impotence in men. However, experts caution that this treatment is only effective — and safe — when used in men who have an initial testosterone deficiency. That's because higher than normal levels produce no added clinical benefit.

DHEA, an adrenal hormone, is used by the body to make testosterone, but it also has many functions of its own, including help to keep the immune system healthy and slowing the aging process.

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References:

  1. Velazquez M, Bellabarba Arata G. Testosterone replacement therapy. Arch Androl 1998;41:79-80.
  2. Burris AS, Banks SM, Carter CS, Davidson JM, Sherin JS. A long-term prospective study of the physiologic and behavioral effects of hormone replacement therapy in untreated hypogonadal men. J Androl 1992;13(4):297-304.
  3. Sternbach S. Age-associated testosterone decline in men: clinical issues for pyschiatry. Am J Psychiatr 1998;155(1):1310-1318.
  4. Halpern CT, Udry JR, Suchindran C. Monthly measures of salivary testosterone predict sexual activity in adolescent males. Arch Sex Behav 1998;278:445-465.
  5. Tenover JL. Male hormone replacement therapy including "andropause." Endocrinol Metab Clin N Am 1998;27(4):969-987.
  6. Morley JE, Kaiser FE. Sexual function with advancing age. Geriatr Med 1989; 73(6):1483-1495.
  7. Morley JE. Endocrine factors in geriatric sexuality. Clin Geriatr Med 1991;7(1):85-93.
  8. Skakkeback N, Bancroft J, Davidson DW, et. al. Androgen replacement with oral testosterone undecanoute in hypogoandal men: A double-blind controlled study. Clin Endocrinl 14:49-55.
  9. Forsberg L, Gustavii B, Hojerback T, Nilsson AL, Olsson AM. One hundred impotent men. Scand J Urol Nephrol 1990;24(83-87).
  10. Gordon D, Beastall GH, Thomson JA, Sturrock RD. Androgenic status and sexual function in males with rheumatoid arthritis and ankylosing spondylitis. Quart J Med 1986;60(231):671-679.

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